Yazar "Akyuva, Yener" için listeleme
-
Are radio-contrast agents commonly used in discography toxic to the intact intervertebral disc tissue cells?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Kaplan, Necati; Çalışkan, Tezcan; Özdemir, Çiğdem; Akyuva, Yener; Ateş, Özkan (Wiley, 2019)In the literature, there have been no studies showing clear results on how radio-contrast pharmaceuticals would affect intact disc tissue cells. In this context, it was aimed to evaluate the effects of iopromide and gadoxetic ... -
Are specific gene expressions of extracellular matrix and nucleus pulposus affected by primary cell cultures prepared from intact or degenerative intervertebral disc tissues?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Kaplan, Necati; Akyuva, Yener; Gönültaş, Aylin; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To determine the gene expression patterns of nucleus pulposus (NP) in cell cultures obtained from degenerated or intact tissues. MATERIAL and METHODS: Whereas 12 of the cases were diagnosed with lumbar disc herniation ... -
The association between different molecular weights of hyaluronic acid and CHAD, HIF-1 alpha, COL2A1 expression in chondrocyte cultures
Yaşar Şirin, Duygu; Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Akyuva, Yener; Kaya, Yasin Emre; Öznam, Kadir; Akkaya, Nuray; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Spandidos Publications Ltd, 2018)The aim of the present study was to investigate the effects of three different formulations of hyaluronic acid (HA): Low molecular weight (MW) Sinovial One((R)), medium MW Viscoplus((R)) and high MW Durolane((R)), on ... -
Can a biodegradable implanted bilayered drug delivery system loaded with BMP-2/BMP-12 take an effective role in the biological repair process of bone-tendon injuries? A preliminary report
Kömür, Baran; Akyuva, Yener; Karaslan, Numan; İşyar, Mehmet; Gümüştaş, Seyit Ali; Yılmaz, İbrahim; Akkaya, Semih; Şirin, Duygu Yaşar; Mutlu, Çağri Ata; Batmaz, Ahmet Güray; Güler, Olcay; Mahiroğulları, Mahir (Hindawi Ltd, 2017)Background. Use of biodegradable and biocompatible materials in the orthopedic surgery is gaining popularity. In this research, the rate of controlled release of a bilayered prototype biomaterial designed to promote ... -
Delivering growth factors through a polymeric scaffold to cell cultures containing both nucleus pulposus and annulus fibrosus
Akyuva, Yener; Kaplan, Necati; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Karaaslan, Numan; Güler, Olcay; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth factor 1 (IGF-1) /bone morphogenetic protein (BMP)-2 following intervertebral disc ... -
Does transcription factor, induced by daptomycin and vancomycin, affect HIF-1α, Chondroadherin, and COL2A1?
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaya, Yasin Emre; Akyuva, Yener; Kaplan, Necati; Doğan, Mustafa; Gümüştaş, Seyit Ali; Ateş, Özkan; Erdem, İlknur (Inonu University School of Medicine, 2018)Aim: In this study, it was firstly aimed to investigate the effect of Daptomycin (DAP) on the proliferation in Vancomycin (VCM)-administered primary chondrocyte cultures and non-drug-administered primary chondrocyte cultures. ... -
Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue
Çalışkan, Tezcan; Şirin, Duygu Yaşar; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Akyuva, Yener; Kaplan, Necati; Kaya, Yasin Emre; Şimşek, Abdullah Talha; Güzelant, Aliye Yıldırım; Ateş, Özkan (Spandidos Publications, 2019)The aim of the present study was to investigate the effects of etanercept (ETA), a tumor necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral disc tissue. ETA is used as a treatment ... -
Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue
Akgün, Feride Sinem; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Şimşek, Abdullah Talha; Kaya, Yasin Emre; Kaplan, Necati; Akyuva, Yener; Çalışkan, Tezcan; Ateş, Özkan (Spandidos Publications, 2019)The present study aimed to evaluate the effects of dipyrone, an indispensable analgesic, anti-pyretic and anti-spasmodic used in emergency departments, on nucleus pulposus and annulus fibrosus cells in vitro. After surgical ... -
Is it possible to treat osteosarcoma using oligonucleotides confined into controlled release drug delivery systems?
Topuk, Savaş; Akyuva, Yener; Karaaslan, Numan; Mutlu, Çağri Ata; Yılmaz, İbrahim; İşyar, Mehmet; Şirin, Duygu Yaşar; Akkaya, Semih; Özbek, Hanefi; Mahiroğulları, Mahir (Bentham Science Publishers Ltd, 2017)Purpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small ... -
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaplan, Necati; Kaya, Yasin Emre; Akyuva, Yener; Gürbüz, Mehmet Sabri; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clinicians, exert toxic effects on human primary nucleus ...